About AddieUP™

There are several different natural based stimulants in AddieUP! Our legendary focus, energy, and attention support formula has no equals. Beware of slick websites that have put some cheap caffeine together with poorly selected herbs that do absolutely nothing but waste your money! AddieUP has had thousands of satisfied customers worldwide continue to order and use our product. We have built our reputation with the most potent and well chosen ingredients possible. Our customers want results, and our formula delivers.

Yerba MateYerba Mate, an invigorator of the mind and body, a natural source of nutrition, and a health promoter par excellence, deserves the attention of every person interested in optimum health. The tea was introduced to colonizing and modern civilizations by the primitive Guarani Indians of Paraguay and Argentina and has seemingly always been the most common ingredient in household cures of the Guarani. Among the native Guarani, on the other hand, the natural use of Mate for healthful purposes has persisted. They use it to boost immunity, cleanse and detoxify the blood, tone the nervous system, restore youthful hair color, retard aging, combat fatigue, stimulate the mind, control the appetite, reduce the effects of debilitating disease, reduce stress, and eliminate insomnia.

Mate (flex paraguariensis) is an evergreen member of the holly family. It grows wild in Argentina, Chile, Peru, and Brazil, but is most abundant in Paraguay where it is also cultivated. The plant is classified vaguely, according to Western herbal medicine, as aromatic, stimulant, bitter, aperient (laxative), astringent, diuretic, purgative, sudorific (sweat inducing), and febrifuge (fever reducing). It contains numerous vitamins and minerals. There is the usual array of resins, fiber, volatile oil, and tannins that characterize many plant substances. And there is also carotene; vitamins A. C, E, B-1, B-2 and B-complex; riboflavin; nicotinic acid; pantothenic acid; biotin; magnesium; calcium; iron; sodium; potassium; manganese; silicon; phosphates; sulfur; hydrochloric acid; chlorophyll; choline; and inositol. In 1964 one group of investigators from the Pasteur Institute and the Paris Scientific Society concluded that Mate contains practically all of the vitamins necessary to sustain life.

In addition to the regular nutrients, Mate contains a substance belonging to a specialized class of chemical compounds called xanthines. Though only small amounts of these substances occur in Mate, their presence has generated a huge amount of attention. The primary xanthine in Yerba-Mate is called Mateine. The substance probably contributes little, if anything, to the overall activity of the plant, but has drawn a disproportionate share of speculation. Some xanthines are obviously less desirable, such as caffeine. Others, such as theophylline and theobromine, have specialized action and a characteristic set of side effects. Although the xanthines have similar chemistries, each has a unique set of properties. Researchers at the Free Hygienic Institute of Hamburg, Germany, concluded that even if there were caffeine in Mate, the amount would be so tiny that it would take 100 tea bags of Mate in a 6-ounce cup of water to equal the caffeine in a 6-ounce serving of regular coffee. Consequently, the active principle in YerbaMate is not caffeine!

There is only one effect that seems to be shared by all xanthines: smooth muscle relaxation. It is this action that makes them (with the exception of caffeine, in which smooth muscle relaxant effects are diminished by other side effects) good clinical dilators of the bronchi and hence useful in the treatment of asthma. Mateine appears, then, to possess the best combination of xanthine properties possible. For example, like other xanthines, it stimulates the central nervous system; but unlike most, it is not habituating or addicting. Likewise, unlike caffeine, it induces better, not worse, attributes of sleep. It is a mild, not a strong, diuretic, as are many xanthines. It relaxes peripheral blood vessels, thereby reducing blood pressure, without the strong effects on the medulla oblongata (end part of the brain connecting to the spine) and heart exhibited by some xanthines. We also know that it improves psychomotor performance without the typical xanthine-induced depressant after effects. Dr. Jose Martin, Director of the National Institute of Technology in Paraguay, writes, “New research and better technology have shown that while Mateine has a chemical constituency similar to caffeine, the molecular binding is different. Mateine has none of the ill effects of caffeine.” And Horacio Conesa, professor at the University of Buenos Aires Medical School, states, “There is not a single medical contraindication” for ingesting Mate. Clinical studies show, in fact, that even individuals with caffeine sensitivities can ingest Mate without adverse reactions.

Guarana-PlantGuarana is a native shrub of South America and the Amazon Basin. The seeds are often crushed and dried by the South American Indians and used as a stimulating drink. The alkaloids found in Guarana work as a stimulant to increase mental l focus and alertness. Guarana inigorates the mind, enhances focus, facilitates though formation and decreases fatigue. It stimulates the cardiovascular system and increases cardiac output. Guarana stimulates the flow of blood in the brain and increases the secretion of the important neurotransmitter serotonin. The substance guaranine in guarana has traces of alkaloids like theophyline and theobromine which work as a stimulant to increase mental and physical stamina and act as a weight loss aid by increasing the metabolic rate and reducing the appetite.

PEA

A remarkable compound, even in its pure form, Beta-Phenylethylamine (PEA), a catecholamine precursor and nutrient found in chocolate, is known to be a very clean stimulant with the remarkable ability to achieve central-nervous-system stimulation without producing nervousness or the jittery feeling associated with other stimulants. Like norepinephrine, the body’s fat-burning hormone, PEA acts on alpha-receptors in the brain, triggering the release of the “feel-good” hormone, dopamine. PEA is also responsible for chocolate’s effect on mood, sense of satiety, reduced food cravings, mild euphoria, as well as increased metabolic rate (by modulating thyroid function). Also known as a neuromodulator, PEA promotes mental alertness, focus and concentration. By regulating catecholamines such as epinephrine (adrenaline) and norepinephrine (noradrenaline) that act on hormone-sensitive lipase, the rate-limiting enzyme in the mobilization of fatty tissue from storage cites, PEA elevates the metabolic rate, ultimately leading to increased fat burning. Unfortunately, PEA is rapidly metabolised in the body by type B monoamine oxidase and has a limited ability to cross the blood-brain barrier, thus preventing it from unleashing its full effects. The challenge was to obtain a form of PEA with a type B monoamine-oxidase inhibitor property. N-Methyl-Beta-Phenylethylamine HCL is an N-Methyl derivative of Beta-Phenylethylamine. This methylated form of PEA is dramatically more potent than pure PEA, and takes PEA’s CNS stimulation and fat-burning several notches higher. While we could have used this compound, we decided to aim still higher. Now enters N-Methyl-Beta-Methylphenylethylamine HCL. This novel and carefully engineered unique agent represents the most potent form of PEA ever developed. It is not an N-Methyl derivative of N-Methyl-Beta-Phenylethylamine HCL, rather an N-Methyl derivative of methylated Beta-Phenylethylamine HCL! It is like “double methylation”! Technically speaking, we astronomically boosted the pharmacokinetic value of PEA! This “double methylated” form unites the finest properties of PEA such as easily crossing the blood-brain barrier, intensifying fat-burning due to optimised beta-receptor agonism while demonstrating unprecedented stability to B monoamine oxidation, implying a longer-lasting and more intensive overall action.

PEA (beta-phenylethylamine)

Beta-phenylethylamine (PEA), a naturally occurring neurohormone/neurotransmitter (chemical signal messenger between nerves) that’s normally synthesized in the brain from the amino acid phenylalanine. PEA has the unique ability to increase the activity of the major neurotransmitters and improve your life functions.

PEA increases the effects of dopamine (for well being and feeling pleasure), norepinephrine (the brain’s stimulant for wakefulness and higher performance), acetylcholine (for improving memory and mental activity), and serotonin (for better mood emotion and impulse control). PEA is a highly-concentrated neurotransmitter in the limbic system (the brain’s emotional center) that increases motivation, physical drive, feelings and social activity.

Longevity, Slower Aging, Youthful Functions

PEA is a powerful weapon for fighting aging. It has a unique ability to help delay aging, extend healthy life span, and restore more youthful mental and physical functions. PEA is a “catecholamine activity enhancer” that according to researchers improves the activity of dopamine/noradrenalin neurons, which have a pivotal role in regulating aging. According to the pioneering research of Dr. Joseph Knoll, a respected neurochemist, pharmacologist and emeritus professor, catecholamine (neurotransmitters such as dopamine and norepinephrine) levels reach a maximum at sexual maturity, and then begin a long, gradual downhill slide. The rate of decline decides how fast a person ages. According to Dr. Knoll, catecholamine levels, learning ability, sexual activity and longevity are all interlinked. The efficiency of your catecholamine brain machinery plays a major role in determining the quality and duration of your life. Higher-performing, longer-living individuals have a more active, more slowly deteriorating catecholamine system than their lower-performing, shorter-living peers.

By rehabilitating our brains’ catecholamine system with enhancer substances (including PEA and its derivatives) it’s possible to transform a lower-performing, shorter-living individual into a better-performing, longer-living one with more youthful mental and physical functions.

Starting around age 25, there’s a lifelong decline in catecholamine neurotransmitters (epinephrine, norepinephrine, and dopamine), a slower decline in the indoleamine neurotransmitter (serotonin), and a shifting imbalance of the catecholamine/serotonin ratio. Catecholamine deficiencies and neurotransmitter imbalances are a principal cause of loss of “hypothalamic sensitivity” for the progressive metabolic shifts that produce aging and the diseases of aging, according to Dr. Vladimir Dilman’s Neuroendocrine Theory of Aging.

According to Dr. Dilman, a renowned Russian biogerontologist, aging is caused by a progressive loss of sensitivity by the hypothalamus (and related structures in the brain) to feedback inhibition from hormones and neurotransmitters. Throughout your lifespan, this loss of sensitivity produces a progressive shifting away from internal balance and altered levels of hormones, neurotransmitters and cell signalers. These are the cause of many post-maturational diseases, accelerated aging, and earlier death. The Neuroendocrine Theory of Aging explains in detail how this causes the major diseases of aging, which contribute to over 85% of early deaths of middle-aged and elderly individuals.

To correct catecholamine deficiencies to help delay aging, prolong life span, prevent aging disorders, and restore youthful biological functions, Dr. Dilman and other aging researchers have suggested: (1) Increase neurotransmitter production and activity; (2) Decrease catecholamine breakdown from MAO-B enzymes; (3) Correct neurotransmitter deficiency and imbalance of the catecholamine/serotonin ratio; (4) Inhibit neurotransmitter re-uptake, to increase intersynaptic neurotransmitter levels; and (5) Correct the decrease in receptor sensitivity and responsiveness of target cells and tissues to neurotransmissions.

PEA has multiple actions that accomplish most all of these functions in helping rehabilitate neurotransmitter systems that fight aging. PEA increases neurotransmitter production and activity, helps correct the neurotransmitter deficiency and imbalance of the catecholamine/serotonin ratio, inhibits neurotransmitter re-uptake, and regulates the responses of cells to neurotransmissions for a stable internal equilibrium.

PEA is the parent compound of l-deprenyl, a catecholamine-enhancing, dopamine-increasing, and neuroprotective compound with proven life-extension actions in animal research. L-deprenyl produces a huge spike in brain PEA that contributes to its anti-aging actions.

The Synergistic Effects of PEA and HordenineFalling in love or having a crush on someone can be a very powerful feeling. The exhilarating rush makes everything else seem insignificant. An often overlooked part of the whole idea, especially when you’re in the middle of the emotions, is that the rush is all a result of a chemical cocktail mixed by the brain. Even though it’s more fun to get the chemicals flowing naturally, two supplements, PEA and Hordenine, can help mimic that kind of intense happiness while improving brain function, boosting physical performance and also helping you burn fat.

Phenylethylamine (PEA) Health Benefits

Phenylethylamine (also known by the much easier to pronounce acronym ‘PEA’) is a natural alkaloid found throughout nature in animals and plants. It is a neuromodulator and neurotransmitter. Individuals often use PEA as a dietary supplement to boost mood and energy. When metabolized, PEA acts similarly to an amphetamine by releasing a special mix of the endorphins norepinephrine and dopamine and speeding up the flow between nerve cells. Due to this, it’s come to be known as the “love molecule” or an infatuation inducing stimulant and creates the high or euphoria felt when in love. There seems to be an optimal range of PEA within the body as people who have problems focusing their attention often have low levels of PEA, while people with certain psychological issues often have abnormally high levels. If PEA sounds like it’s too good to be true, that’s because it is. When used alone, PEA is quickly made inactive by monoamine oxidase (MAO). This means very little reaches the brain and even if it does, the effects don’t last very long.

The Benefits of Hordenine

This is where hordenine comes in. Hordenine is an alkaloid extracted from specific type of cactus and in the class of PEA-related chemicals. It also affects levels of norepinephrine within the body and is used as a stand alone supplement for energy, weight loss, body composition, and improved cognitive function. But when it relates to PEA, the most sought after effects of hordenine are for it acting as an MAO inhibitor. Since MAO quickly breaks down PEA when it’s metabolized, the effects are short lasting. But when combined with the MAOI-like effects of a supplement like hordenine, the positive feelings from PEA can carry on much longer and possibly be amplified.

While the chemical effects of stacking PEA and hordenine are the same, they benefit users in a variety of ways from a planned euphoria during social events on the weekends to energetic, focused workouts. The main uses of PEA/Hordenine are:

Higenamine hcl, commonly known as demethyl coclaurine, and norcoclaurine in chemical field. From wikipedia, higenamine is defined as a chemical compound found in a variety of plants including Nandina domestica, Aconitum carmichaelii, Asarum heterotropioides, Galium divaricatum, Annona squamosa, and Nelumbo nucifera (lotus seeds). Higenamine has a long history of use in traditional medicine in ancient China.

Higenamine works as a stimulant to help increase focus and mental clarity. As many of you know, many stimulants tend to restrict the veins causing them to inhibit the production of Nitric Oxide. Some research is showing that higenamine doesn’t affect nitric oxide production like other stimulants. This is really an amazing break through for lifters and explosive athletes. Imagine a product where you can get the most out of your Nitric Oxide supplement and still get stimulating energy, this is what Norcoclaurine is starting to do. The functions of higenamine hcl are summarized as:

  1. Increase focus and mental clarity.(as a stimulant with no restriction of the veins)
  2. Function as a fat burner. Higenamine is a molecule that is part of the Nandina plant that has traditionally been used as an anti-asthmatic. Since Ephedrine and its fat burning mechanism are also anti-asthmatic, Higenamine might be a fat burner. Higenamine is a catecholamine-like structure that interacts with the same class of receptors that the fat burners Synephrine and Ephedrine do.
  3. Interactions with Sexuality. higenamine appears to induce relaxation and promote erection through beta-adrenergic interactions.The inhibition of NO was seen as an injection of 10mg/kg bodyweight, a large dose

Choline is an essential nutrient that is usually classified with the B vitamins. Research indicates that choline has been found to positively affect learning abilities and memory functioning, as well as many other conditions.

What is Choline?

Although it is not officially a B vitamin, it may be classified as one soon. Choline is required by the body for a number of important processes, including liver protection, cell membrane structure, and maintaining neurotransmitter functioning. Most authorities classify choline as an essential nutrient or micronutrient. The body manufacturers a small amount of choline, but it is usually not as much as is required for optimal health, so medical experts recommend getting additional choline through the diet or in the form of supplements. Foods that are good sources of choline include meat, liver, fish, legumes, beans, nuts, peas, eggs, wheat germ, and spinach.

Choline benefits

Research on the benefits of choline is continuing, but according to studies so far, adequate choline intake is associated with preventing or resolving a number of diseases and conditions.

Choline is also a critical nutrient for pregnant and breastfeeding mothers, as it helps to prevent neural tube defects in developing fetuses and promotes healthy brain development in newborns.

Many athletes use choline for delaying the onset of fatigue in sports which require endurance. Choline is utilized by body builders, as well.

Choline side effects

When taken as directed by health professionals, choline is not associated with any harmful side effects. In very rare instances, excessive choline intake has been associated with increased body temperature, sweating, and loss of appetite.

Choline should be taken earlier in the day, as it can interfere with sleep if consumed too close to bedtime.

How does Choline help brain function?

Choline is a “building block” for the neurotransmitter acetylcholine, which promotes intelligence and memory in the brain. Research on pregnant rats indicates that there is a correlation between choline intake and the ability to perform mental tasks of the offspring. Choline has been found to promote optimal memory functioning and to promote the ability to learn, as well as a preventative agent for protecting against dementia and Alzheimer’s disease.

In other medical studies, choline has emerged as a helpful nutrient in lowering the levels of an amino acid in the blood called homocysteine. This is important because elevated levels of homocysteine are linked to a higher risk of cardiovascular disease. Additional research has shown that choline has also been associated with properties that protect the liver from certain diseases and to help repair liver damage which has already occurred.

Natural Support for Brain Function

Huperzine A is a plant alkaloid derived from the Chinese club moss plant Huperzia serrata. It has been found to protect neurotransmitters in the brain. Specifically, it protects acetylcholine, a messenger molecule in the central and peripheral nervous system that is strongly involved in vital functions such as cognition, concentration, and memory.

It’s All About Balance

When people have loss of brain function, insufficient messenger molecules, like the important neurotransmitter acetylcholine, remain to do their jobs. It is thought that in aging people, or people with compromised health, the enzyme acetylcholinesterase does not keep balance in the brain but instead wipes out too much acetylcholine. The brain loses function. Huperzine A is what keeps the acetylcholinesterase in check, making sure that enough messenger molecules remain at work. Huperzine A protects the messenger molecules, the acetylcholine.

Heightened Cholinergic Function

The cholinergic function is the pathway or circuit that neurons travel to relay signals, which in turn is how memory and cognition work. Slight cholinergic deterioration plays a role in benign memory changes associated with healthy aging, but it is also a factor of more severe cognitive declines. Brain choline decreases naturally with age, however Huperzine A appears to protect the number, size and function of cholinergic neurons. It has been shown to affect the survival and outgrowth of central cholinergic neurons.

All Ages Can Benefit

Worldwide studies have shown the efficacy of Huperzine A in memory and learning in adolescents, particularly benefiting students in scores of accumulation, recognition, association, factual memory, and recitations.

Wellness Revolution

Age-related cognitive decline is not inevitable. Through a deeper understanding of brain chemistry, youthful functions can be maintained. Huperzine-A is a cutting edge Nootropic that has shown promise in combating the aging process.

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