About AddieUP™

There are several different natural based stimulants in AddieUP! Our legendary brain focus, energy, and attention supplement is the market leader. Beware of slick websites that have put some inexpensive caffeine together with poorly selected herbs or nootropics that do absolutely nothing but waste your money! AddieUP has had thousands of satisfied customers worldwide who continue to order and use our product. We have built our reputation with the most potent and well chosen ingredients possible. Our customers want results, and our formula delivers for them.*

Yerba mate deserves the attention of every person interested in optimum health. Yerba mate (flex paraguariensis) is an evergreen member of the holly family. It grows wild in Argentina, Chile, Peru, and Brazil, but is most abundant in Paraguay where it is also cultivated. The plant is classified according to western herbal remedy, and as a stimulant that is aromatic, bitter, and purgative (cleansing). Yerba mate contains numerous vitamins, minerals, and anti-oxidants. There is the usual array of resins, fiber, volatile oil, and tannins that characterize many plant substances like yerba mate. And there is also carotene, vitamins A. C, E, B-1, B-2 and B-complex, riboflavin, nicotinic acid, pantothenic acid, biotin, magnesium, calcium, manganese and silicon. In 1964 one group of investigators from the Pasteur Institute and the Paris Scientific Society concluded that yerba mate contains practically all of the vitamins necessary to sustain life.

The tea was introduced to colonizing and modern civilizations by the primitive guarani Indians of Paraguay and Argentina and has been among most common ingredient in their households. Among the native guarani the natural use of yerba mate for healthful purposes has persisted. They use it to boost immunity, tone the nervous system, combat fatigue, stimulate the mind, and to reduce stress.

In addition to regular nutrients, yerba mate contains a substance belonging to a specialized class of chemical compounds called xanthines. Though only small amounts of these substances occur in yerba mate, their presence has generated considerable attention. The primary xanthine in yerba mate is called mateine. The substance probably contributes little, if anything, to the overall activity of the plant, but has drawn a disproportionate share of speculation. Some xanthines are obviously less desirable, such as caffeine. Others, such as theophylline and theobromine, have specialized action and a characteristic set of effects. Although the xanthines have similar chemistries, each has a unique set of properties. Researchers at the free hygienic institute of Hamburg, Germany, concluded that even if there were caffeine in yerba mate, the amount would be so tiny that it would take 100 tea bags of yerba mate in a six ounce cup of water to equal the caffeine in a six ounce serving of regular coffee. Consequently, the active principle in yerba mate is not caffeine.

There is only one effect that seems to be shared by all xanthines- smooth muscle relaxation1. It is this action that makes them (with the exception of caffeine, in which smooth muscle relaxant effects are diminished by other side effects). Mateine appears, then, to possess the best combination of xanthine properties possible. For example, like other xanthines, it stimulates the central nervous system2. Also, is not habit forming or addicting. Likewise, unlike caffeine, it induces better, not worse, attributes of sleep. It is a mild, not a strong, diuretic, as are many xanthines. It relaxes peripheral blood vessels, without the strong effects on the medulla oblongata (end part of the brain connecting to the spine) and heart exhibited by some xanthines. We also know that it improves psychomotor performance without the typical xanthine-induced depressant after effects. Dr. Jose Martin, Director of the National Institute of Technology in Paraguay, writes, “New research and better technology have shown that while mateine has a chemical constituency similar to caffeine, the molecular binding is different. mateine has none of the ill effects of caffeine.” And Horacio Conesa, professor at the university of Buenos Aires Medical School, states, “There is not a single medical contraindication” for ingesting mate. Clinical studies show, in fact, that even individuals with caffeine sensitivities can ingest mate without adverse reactions.*

Guarana is a native shrub of South America and the Amazon Basin. The seeds are often crushed and dried by the South American Indians and used as a stimulating drink. The alkaloids found in guarana work as a stimulant to increase mental focus and alertness. Guarana invigorates the mind, enhances focus, and decreases fatigue. It stimulates the cardiovascular system and increases cardiac output. Guarana may stimulate the flow of blood in the brain and also may increase the secretion of the important neurotransmitter serotonin. The substance guaranine in guarana has traces of alkaloids like theobromine, which work as a stimulant to increase mental and physical stamina.*

The Benefits of Hordenine

Hordenine is an alkaloid extracted from specific type of cactus and in the class of PEA-related chemicals. It also affects levels of norepinephrine within the body and is used as a stand alone supplement for energy, weight loss, body composition, and improved cognitive function.The most sought after effects of hordenine are for it acting with other stimulants. When combined with the effects of a supplement like hordenine, the positive feelings may carry on much longer and possibly be amplified. This is still a matter of debate.*

While the chemical effects of hordenine are the same, they benefit users in a variety of ways, from energetic weekends, to energetic, focused workouts. The main uses of hordenine may be to:

  • Induce a positive mood*
  • Focus and concentration*
  • Energy*
  • Reduction of fatigue*

Higenamine hcl, commonly known as demethyl coclaurine, and norcoclaurine in chemical field. From wikipedia, higenamine is defined as a chemical compound found in a variety of plants including nandina domestica, , asarum, galium divaricatum, and nelumbo nucifera. Higenamine has a long history of use in traditional medicine in ancient China.

Higenamine works as a stimulant and may help with focus and mental clarity. Many stimulants tend to restrict the veins, causing them to inhibit the production of nitric oxide. This is really an amazing break through for lifters and athletes. Imagine a product where you can get the most out of your nitric oxide supplement and still get stimulating energy, this is what norcoclaurine may be able to do. The functions of higenamine may be summarized as:

  1. Increase focus and mental clarity.(as a stimulant with no restriction of the veins)*
  2. Higenamine is a molecule that is part of the Nandina plant. Since Ephedrine and its fat burning mechanism are similar, higenamine might be thermogenic.
  3. Higenamine is a catecholamine-like structure that interacts with the same class of receptors that the synephrine and ephedrine do.
  4. Higenamine appears to induce relaxation and promote promote blood flow through beta-adrenergic interactions.*

What is Choline?

Choline is an essential nutrient that is usually classified with the B vitamins. Choline has been found to positively affect learning abilities and memory functioning.*

Although it is not officially a B vitamin, it may be classified as one soon. Choline is required by the body for a number of important processes, including liver protection, cell membrane structure, and maintaining neurotransmitter functioning. Most authorities classify choline as an essential nutrient or micronutrient. The body manufacturers a small amount of choline, but it is usually not as much as is required for optimal health, so medical experts recommend getting additional choline through the diet or in the form of supplements. Foods that are good sources of choline include meat, liver, fish, legumes, beans, nuts, peas, eggs, wheat germ, and spinach.

Choline benefits

Research on the benefits of choline is continuing, but according to studies so far, adequate choline intake may be associated with preventing or resolving a number of conditions.Choline is also a important nutrient for pregnant and breastfeeding mothers, as it helps to prevent neural tube defects in developing fetuses and promotes healthy brain development in newborns. Many athletes use choline for delaying the onset of fatigue in sports which require endurance. Choline is utilized by body builders as well.*

Choline side effects

When taken as directed by health professionals, choline is not associated with any harmful side effects. In very rare instances, excessive choline intake has been associated with increased body temperature, sweating, and loss of appetite. Choline should be taken earlier in the day, as it can interfere with sleep if consumed too close to bedtime.*

How can Choline help brain function?

Choline is a “building block” for the neurotransmitter acetylcholine, which may promote memory in the brain. Research on pregnant rats indicates that there is a correlation between choline intake and the ability to perform mental tasks of the offspring. Choline has been found to promote optimal memory functioning and to promote the ability to learn. In other medical studies, choline has emerged as a helpful nutrient in lowering the levels of an amino acid in the blood called homocysteine. This is important because elevated levels of homocysteine are linked to a higher risk of cardiovascular disease.*

Natural Support for Brain Function

Huperzine A is a plant alkaloid derived from the Chinese club moss plant huperzia serrata. It has been found to affect and possibly protect neurotransmitters in the brain. Specifically, it protects acetylcholine, a messenger molecule in the central and peripheral nervous system that is strongly involved in vital functions such as cognition, concentration, and memory.*

It's All About Balance

When people have loss of brain function, insufficient messenger molecules, like the important neurotransmitter acetylcholine, remain to do their jobs. It is thought that in aging people, or people with compromised health, the enzyme acetylcholinesterase does not keep balance in the brain but instead wipes out too much acetylcholine. The brain can then possibly lose its proper function. Huperzine is may keep the acetylcholinesterase in check, making sure that enough messenger molecules remain at work. Huperzine may protect the messenger molecules as well.*

Heightened Function

The cholinergic function is the pathway or circuit that neurons travel to relay signals, which in turn is how memory and cognition work. Slight cholinergic deterioration plays a role in benign memory changes associated with healthy aging, but it is also a factor of more severe cognitive declines. Brain choline decreases naturally with age, however Huperzine A may protect the number, size and function of cholinergic neurons. It has been shown to affect the survival and outgrowth of central cholinergic neurons.*

All Ages Can Benefit

Worldwide studies have shown the efficacy of huperzine in memory and learning in adolescents, particularly benefiting students in scores of accumulation, recognition, association, factual memory, and recitations.*

Wellness Revolution

Age-related cognitive decline is not inevitable. Through a deeper understanding of brain chemistry, youthful functions can be maintained. Huperzine is a cutting edge nootropic that has shown promise. It is part of a ongoing wellness revolution that has begun with the increased use of nootropics.